|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0039194,
umls-concept:C0382839,
umls-concept:C0439097,
umls-concept:C0871261,
umls-concept:C1416682,
umls-concept:C1523873,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1704632,
umls-concept:C1705241,
umls-concept:C1706817,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911692
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
1998-4-23
|
|
pubmed:abstractText |
Viral, bacterial, protozoal, and cancer-associated Ags elicit strong responses in human gammadelta T lymphocytes. The majority of these cells in the peripheral blood express the Vgamma9Vdelta2-encoded TCR and recognize nonpeptidic phosphoantigens without an apparent MHC restriction. We have shown that Vgamma9Vdelta2 T cells express the inhibitory CD94/NKG2 receptor for HLA class I molecules. The anti-CD94 mAb inhibits 1) the Vgamma9Vdelta2 T cell proliferation in response mycobacterial phosphoantigens and 2) the HIV-induced Vgamma9Vdelta2 T cell expansion. Vgamma9Vdelta2 T cells stimulated with nonpeptidic mycobacterial antigens produce IFN-gamma and TNF-alpha. Signaling through the CD94/NKG2 receptor interferes with the synthesis of these cytokines. The CD94/HLA class I interaction is also involved in the cytotoxic activity of Vgamma9Vdelta2 T cells. The Vgamma9Vdelta2 T cell regulation through the CD94 receptor may be important for the potentially dual function in innate immunity, i.e., 1) NK-like and 2) TCR ligand-induced cytolytic activities.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/KLRC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
159
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6009-17
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:9550399-Antigens, Bacterial,
pubmed-meshheading:9550399-Antigens, CD,
pubmed-meshheading:9550399-Antigens, Viral,
pubmed-meshheading:9550399-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:9550399-Gene Rearrangement, delta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:9550399-Genes, Immunoglobulin,
pubmed-meshheading:9550399-HIV-1,
pubmed-meshheading:9550399-Histocompatibility Antigens Class I,
pubmed-meshheading:9550399-Humans,
pubmed-meshheading:9550399-Killer Cells, Natural,
pubmed-meshheading:9550399-Lectins, C-Type,
pubmed-meshheading:9550399-Lymphocyte Activation,
pubmed-meshheading:9550399-Membrane Glycoproteins,
pubmed-meshheading:9550399-Mycobacterium fortuitum,
pubmed-meshheading:9550399-NK Cell Lectin-Like Receptor Subfamily C,
pubmed-meshheading:9550399-NK Cell Lectin-Like Receptor Subfamily D,
pubmed-meshheading:9550399-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9550399-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:9550399-Receptors, Immunologic,
pubmed-meshheading:9550399-Receptors, Mitogen,
pubmed-meshheading:9550399-Receptors, Natural Killer Cell,
pubmed-meshheading:9550399-T-Lymphocyte Subsets,
pubmed-meshheading:9550399-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9550399-Tumor Cells, Cultured
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
CD94/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V gamma 9V delta 2 T lymphocytes.
|
|
pubmed:affiliation |
Department of Biology, University of Rome Tor Vergata, Italy. poccia@utovrm.it
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
