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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1998-6-1
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pubmed:abstractText |
The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM + 1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0031-1820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
116 ( Pt 3)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
219-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9550214-Adjuvants, Immunologic,
pubmed-meshheading:9550214-Animals,
pubmed-meshheading:9550214-BCG Vaccine,
pubmed-meshheading:9550214-Cercopithecidae,
pubmed-meshheading:9550214-Cricetinae,
pubmed-meshheading:9550214-Disease Models, Animal,
pubmed-meshheading:9550214-Dose-Response Relationship, Immunologic,
pubmed-meshheading:9550214-India,
pubmed-meshheading:9550214-Leishmania donovani,
pubmed-meshheading:9550214-Leishmania major,
pubmed-meshheading:9550214-Leishmaniasis, Visceral,
pubmed-meshheading:9550214-Male,
pubmed-meshheading:9550214-Protozoan Vaccines,
pubmed-meshheading:9550214-Spleen,
pubmed-meshheading:9550214-Vaccination,
pubmed-meshheading:9550214-Vaccines, Inactivated
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pubmed:year |
1998
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pubmed:articleTitle |
Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG.
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pubmed:affiliation |
Division of Parasitology, Central Drug Research Institute, Lucknow, India. root@cscdri.ren.nic.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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