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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1998-5-7
|
| pubmed:abstractText |
A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of YM022 and RP72540. The gastrin/cholecystokinin (CCK)-B and CCK-A receptor antagonist activities of these compounds were evaluated by investigation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that N-methyl-N-phenyl-2-[2-[N-(N-methyl-N-phenyl-carbamoylmethyl)-N-[2 -[3-(3- methylphenyl)ureido]acetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity for gastrin/CCK-B receptors and high selectivity over CCK-A receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0009-2363
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
434-44
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9549885-Acetamides,
pubmed-meshheading:9549885-Animals,
pubmed-meshheading:9549885-CHO Cells,
pubmed-meshheading:9549885-Cholecystokinin,
pubmed-meshheading:9549885-Cricetinae,
pubmed-meshheading:9549885-Gastrins,
pubmed-meshheading:9549885-Gene Transfer Techniques,
pubmed-meshheading:9549885-Humans,
pubmed-meshheading:9549885-Phenylurea Compounds
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors.
|
| pubmed:affiliation |
New Product Research Laboratories III, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|