| pubmed-article:9548500 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0235557 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:9548500 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:9548500 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9548500 | pubmed:dateCreated | 1998-4-20 | lld:pubmed |
| pubmed-article:9548500 | pubmed:abstractText | Pulmonary granulomatous inflammation modulated by IFN-gamma and IL-12 is also associated with augmented inducible nitric oxide synthase (NOS II). To address the role of increased nitric oxide synthesis in this model, mice received daily i.p. injections of NG-nitro-L-arginine-methyl ester (L-NAME; 8 mg/kg) during both the 2-wk immunization period with purified protein-derivative (PPD) and the subsequent lung challenge with PPD-coated Sepharose beads. Other groups of animals received saline, L-NAME or NG-nitro-D-arginine-methyl ester (D-NAME; 8 mg/kg) during the pulmonary embolization period and not the PPD sensitization period. On day 4 post-PPD bead challenge, PCR analysis of the whole lung revealed that NOS II expression appeared to be similar in both of the L-NAME treatment protocols. L-NAME-treated mice in both dosing protocols had lung lesions that were significantly larger than granuloma lesions measured in mice that received saline or D-NAME. The enlarged lesions from L-NAME-treated mice contained markedly greater numbers of neutrophils and eosinophils. Equivalent numbers of PPD-activated dispersed cells from whole lungs of L-NAME-treated mice produced significantly higher levels of IL-4 and IL-10 and smaller amounts of IL-12 and IFN-gamma compared with similar lung cultures derived from control or D-NAME-treated mice. Levels of C-C chemokines such as monocyte chemoattractant protein-1 (MCP-1), C10, and macrophage inflammatory protein-1alpha (MIP-1alpha) were also significantly elevated in lung cultures from L-NAME-treated mice compared with controls. Thus, nitric oxide regulates the size and cellular composition of the Th1-type lung granuloma, possibly through its effects on the cytokine and chemokine profile associated with this lesion. | lld:pubmed |
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| pubmed-article:9548500 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9548500 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9548500 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9548500 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9548500 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:KunkelS LSL | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:ChensueS WSW | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:StrieterR MRM | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:LukacsN WNW | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:HogaboamC MCM | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:HuffnagleG... | lld:pubmed |
| pubmed-article:9548500 | pubmed:author | pubmed-author:SteinhauserM... | lld:pubmed |
| pubmed-article:9548500 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9548500 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9548500 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:9548500 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9548500 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9548500 | pubmed:pagination | 5585-93 | lld:pubmed |
| pubmed-article:9548500 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9548500 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9548500 | pubmed:articleTitle | Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. | lld:pubmed |
| pubmed-article:9548500 | pubmed:affiliation | Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602, USA. | lld:pubmed |
| pubmed-article:9548500 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9548500 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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