Linked Life Data

9548234

Source:http://linkedlifedata.com/resource/pubmed/id/9548234

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1998-6-5
pubmed:abstractText
Apoptosis is an active process of cell death characterized by distinct morphological features, and is often the end result of a genetic programme of events, i.e. programmed cell death (PCD). There is growing evidence supporting a role for apoptosis in some neurodegenerative diseases. This conclusion is based on DNA fragmentation studies and findings of increased levels of pro-apoptotic genes in human brain and in in vivo and in vitro model systems. Additionally, there is some evidence for a loss of neurotrophin support in neurodegenerative diseases. In Alzheimer's disease, in particular, there is strong evidence from human brain studies, transgenic models and in vitro models to suggest that the mode of nerve cell death is apoptotic. In this review we describe the evidence implicating apoptosis in neurodegenerative diseases with a particular emphasis on Alzheimer's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0334-1763
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Apoptosis, neurotrophic factors and neurodegeneration.
pubmed:affiliation
Department of Pharmacology and Clinical Pharmacology, Medicine and Health Sciences Campus, The University of Auckland, New Zealand.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't