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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1998-6-16
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pubmed:abstractText |
Neural networks have been trained to predict the subcellular location of proteins in prokaryotic or eukaryotic cells from their amino acid composition. For three possible subcellular locations in prokaryotic organisms a prediction accuracy of 81% can be achieved. Assigning a reliability index, 33% of the predictions can be made with an accuracy of 91%. For eukaryotic proteins (excluding plant sequences) an overall prediction accuracy of 66% for four locations was achieved, with 33% of the sequences being predicted with an accuracy of 82% or better. With the subcellular location restricting a protein's possible function, this method should be a useful tool for the systematic analysis of genome data and is available via a server on the world wide web.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-1478671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-1607012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-7795533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8066087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8145256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8332529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8688087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8811733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-8948633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-9016499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9547285-9067612
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2230-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9547285-Amino Acids,
pubmed-meshheading:9547285-Cell Compartmentation,
pubmed-meshheading:9547285-Computer Communication Networks,
pubmed-meshheading:9547285-Databases, Factual,
pubmed-meshheading:9547285-Eukaryotic Cells,
pubmed-meshheading:9547285-Forecasting,
pubmed-meshheading:9547285-Neural Networks (Computer),
pubmed-meshheading:9547285-Prokaryotic Cells,
pubmed-meshheading:9547285-Proteins,
pubmed-meshheading:9547285-Reproducibility of Results
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pubmed:year |
1998
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pubmed:articleTitle |
Using neural networks for prediction of the subcellular location of proteins.
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pubmed:affiliation |
The Sanger Centre, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. areinha@sanger.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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