| pubmed-article:9546817 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9546817 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:9546817 | lifeskim:mentions | umls-concept:C0041432 | lld:lifeskim |
| pubmed-article:9546817 | lifeskim:mentions | umls-concept:C0043297 | lld:lifeskim |
| pubmed-article:9546817 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9546817 | pubmed:dateCreated | 1998-4-16 | lld:pubmed |
| pubmed-article:9546817 | pubmed:abstractText | The hypothesis that a low concordance rate in monozygotic (MZ) twins with systemic lupus erythematosus (SLE) may be accounted for by differences in X-chromosome inactivation was examined. Five MZ twin pairs, four discordant and one concordant, were recruited, zygosity confirmed by DNA fingerprinting, and their pattern of X-chromosome inactivation in DNA samples prepared from peripheral blood and buccal cells were examined. X-chromosome inactivation was assessed by the methylation status of the CpG region near trinucleotide repeats in exon 1 of the androgen receptor gene on X-chromosome after digestion with the methylation-sensitive enzyme HpaII or HhaI and PCR amplification. X-chromosome inactivation patterns were found to be the same between affected and non-affected twins in all four discordant twin pairs, with random patterns in two pairs and skewed patterns in the others. The concordant twins demonstrated the same random patterns. X-chromosome inactivation was also examined from buccal smear DNA and shown to have the same pattern as that noted from peripheral blood DNA in one informative twin pair. Differences in X-chromosome inactivation patterns were not observed in these five MZ twin pairs. The results could not support the hypothesis that differences in X-chromosome inactivation is the mechanism accounting for the low concordance rate noted in MZ twins with SLE. | lld:pubmed |
| pubmed-article:9546817 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9546817 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9546817 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9546817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9546817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9546817 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9546817 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9546817 | pubmed:issn | 0891-6934 | lld:pubmed |
| pubmed-article:9546817 | pubmed:author | pubmed-author:ParfittAA | lld:pubmed |
| pubmed-article:9546817 | pubmed:author | pubmed-author:GrennanD MDM | lld:pubmed |
| pubmed-article:9546817 | pubmed:author | pubmed-author:HuangQQ | lld:pubmed |
| pubmed-article:9546817 | pubmed:author | pubmed-author:ManoliosNN | lld:pubmed |
| pubmed-article:9546817 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9546817 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:9546817 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9546817 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9546817 | pubmed:pagination | 85-93 | lld:pubmed |
| pubmed-article:9546817 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:9546817 | pubmed:meshHeading | pubmed-meshheading:9546817-... | lld:pubmed |
| pubmed-article:9546817 | pubmed:meshHeading | pubmed-meshheading:9546817-... | lld:pubmed |
| pubmed-article:9546817 | pubmed:meshHeading | pubmed-meshheading:9546817-... | lld:pubmed |
| pubmed-article:9546817 | pubmed:meshHeading | pubmed-meshheading:9546817-... | lld:pubmed |
| pubmed-article:9546817 | pubmed:meshHeading | pubmed-meshheading:9546817-... | lld:pubmed |
| pubmed-article:9546817 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9546817 | pubmed:articleTitle | X-chromosome inactivation in monozygotic twins with systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:9546817 | pubmed:affiliation | Department of Rheumatology, Royal North Shore Hospital St. Leonards, NSW, Australia. | lld:pubmed |
| pubmed-article:9546817 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9546817 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:9546817 | pubmed:publicationType | Twin Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9546817 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9546817 | lld:pubmed |
