rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1998-5-13
|
pubmed:abstractText |
A better understanding of the causative agent's biology and the definition of new targets for the development of drugs and/or specific immune responses is necessary to face the spred of drug-resistant malaria in developing countries and the absence of an efficient vaccine against this most important infectious disease. Non-detergent sulphobetaines enhance the recovery and isoelectric focussing of active Plasmodium falciparum proteases, cytoskeleton-associated proteins and Maurer's cleft-associated proteins. This is a significant advantage for the purification of such proteins and might help pinpoint their role for red blood cell rupture and merozoite release.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0014-2956
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
252
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
537-41
|
pubmed:dateRevised |
2007-7-23
|
pubmed:meshHeading |
pubmed-meshheading:9546671-Animals,
pubmed-meshheading:9546671-Betaine,
pubmed-meshheading:9546671-Blood Proteins,
pubmed-meshheading:9546671-Cytoskeletal Proteins,
pubmed-meshheading:9546671-Cytoskeleton,
pubmed-meshheading:9546671-Endopeptidases,
pubmed-meshheading:9546671-Erythrocyte Membrane,
pubmed-meshheading:9546671-Erythrocytes,
pubmed-meshheading:9546671-Indicators and Reagents,
pubmed-meshheading:9546671-Isoelectric Focusing,
pubmed-meshheading:9546671-Membrane Proteins,
pubmed-meshheading:9546671-Molecular Weight,
pubmed-meshheading:9546671-Plasmodium falciparum,
pubmed-meshheading:9546671-Protozoan Proteins,
pubmed-meshheading:9546671-Solubility
|
pubmed:year |
1998
|
pubmed:articleTitle |
Non-detergent sulphobetaines enhance the recovery of membrane and/or cytoskeleton-associated proteins and active proteases from erythrocytes infected by Plasmodium falciparum.
|
pubmed:affiliation |
Unit of Experimental Parasitology, Institut Pasteur, Paris, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|