Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
1998-4-30
|
| pubmed:abstractText |
Laser-induced fluorescence (LIF) of tissues depends on their biochemical and histomorphologic characteristics. LIF spectroscopic properties of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced precancerous and early cancerous lesions in a hamster buccal pouch mucosa model were studied. Fluorescence spectra from neoplastic lesions showed a characteristic fluorescence peak in the red region of the visible spectrum centered between 630 and 640 nm when excited with 410-nm light. Using this as a diagnostic criterion, 45 of 49 lesions studied were correctly diagnosed, including early dysplastic lesions. Follow-up study of four dysplastic lesions over 2 weeks revealed an increase in red fluorescence intensity. The findings of these experiments suggest that LIF spectroscopy may be a valuable noninvasive technique not only for early diagnosis of head and neck cancer, but also to probe a possible biochemical surrogate biomarker in the follow-up of suspected lesions.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0023-852X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
108
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
471-5
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9546254-9,10-Dimethyl-1,2-benzanthracene,
pubmed-meshheading:9546254-Animals,
pubmed-meshheading:9546254-Carcinogens,
pubmed-meshheading:9546254-Carcinoma, Squamous Cell,
pubmed-meshheading:9546254-Carcinoma in Situ,
pubmed-meshheading:9546254-Cell Transformation, Neoplastic,
pubmed-meshheading:9546254-Color,
pubmed-meshheading:9546254-Cricetinae,
pubmed-meshheading:9546254-Disease Models, Animal,
pubmed-meshheading:9546254-Disease Progression,
pubmed-meshheading:9546254-Fluorescence,
pubmed-meshheading:9546254-Follow-Up Studies,
pubmed-meshheading:9546254-Hyperplasia,
pubmed-meshheading:9546254-Lasers,
pubmed-meshheading:9546254-Leukoplakia, Oral,
pubmed-meshheading:9546254-Male,
pubmed-meshheading:9546254-Mesocricetus,
pubmed-meshheading:9546254-Mouth Mucosa,
pubmed-meshheading:9546254-Mouth Neoplasms,
pubmed-meshheading:9546254-Neoplasm Invasiveness,
pubmed-meshheading:9546254-Precancerous Conditions,
pubmed-meshheading:9546254-Spectrometry, Fluorescence,
pubmed-meshheading:9546254-Stomatitis,
pubmed-meshheading:9546254-Tumor Markers, Biological
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Diagnosis of head and neck precancerous lesions in an animal model using fluorescence spectroscopy.
|
| pubmed:affiliation |
Department of Otolaryngology Head and Neck Surgery, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|