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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-6-8
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pubmed:abstractText |
The nervous (nr) mutant mouse displays two gross recessive traits: both an exaggeration of juvenile hyperactivity and a pronounced ataxia become apparent during the third and fourth postnatal weeks. Using an intersubspecific intercross, we have established a high-resolution map of a segment of mouse chromosome 8 that places the nr locus in a genomic segment defined by D8Rck1 on the centromeric end and D8Mit3 on the telomeric end. This map position places the nr locus within the BALB/cGr congenic region of the C3HeB/ FeJ-nr strain, confirming the accuracy of our study. We used this map position to identify and evaluate three genes-ankyrin 1, cortexin, and farnesyltransferase-as candidates for the nr gene. These three genes were eliminated from consideration but allowed us to establish the conservation of synteny between the region containing the nr locus and a segment of the short arm of human chromosome 8 (8p21-p11.2). Finally, the incomplete penetrance of the nr phenotype led us to perform a screen for modifier loci, and we present evidence that such a nervous modifier locus may exist on mouse chromosome 5.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
346-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9545640-Adjuvants, Immunologic,
pubmed-meshheading:9545640-Alkyl and Aryl Transferases,
pubmed-meshheading:9545640-Animals,
pubmed-meshheading:9545640-Ankyrins,
pubmed-meshheading:9545640-Ataxia,
pubmed-meshheading:9545640-Chromosome Mapping,
pubmed-meshheading:9545640-Chromosomes, Human, Pair 8,
pubmed-meshheading:9545640-Farnesyltranstransferase,
pubmed-meshheading:9545640-Genes, Recessive,
pubmed-meshheading:9545640-Genetic Linkage,
pubmed-meshheading:9545640-Genetic Markers,
pubmed-meshheading:9545640-Haplotypes,
pubmed-meshheading:9545640-Humans,
pubmed-meshheading:9545640-Hyperkinesis,
pubmed-meshheading:9545640-Mice,
pubmed-meshheading:9545640-Mice, Inbred BALB C,
pubmed-meshheading:9545640-Mice, Inbred C3H,
pubmed-meshheading:9545640-Mice, Neurologic Mutants,
pubmed-meshheading:9545640-Microsatellite Repeats,
pubmed-meshheading:9545640-Peptides
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pubmed:year |
1998
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pubmed:articleTitle |
A high-resolution genetic map of the nervous locus on mouse chromosome 8.
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pubmed:affiliation |
Howard Hughes Medical Institute, Laboratory of Molecular Biology, Rockefeller University, New York, New York 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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