Linked Life Data

9545428

Source:http://linkedlifedata.com/resource/pubmed/id/9545428

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-5-28
pubmed:abstractText
We present the synthesis, characterization and initial structure-function analysis of a new class of bioactive agent that allows the application of techniques from colloid science to biological surfaces. Stable colloidal suspensions can be generated by immobilizing a dense brush of soluble polymer at the colloidal surface, creating a zone protected against the adhesion of approaching particles, a phenomenon termed polymeric steric stabilization. This is often accomplished for aqueous colloidal dispersions using adsorbing block copolymers. We demonstrate that water-soluble block copolymers can be designed to adsorb onto heterogeneous biological surfaces and block cell-cell and cell-surface adhesion, using polymer compositions and architectures that are quite different from surfactants used for stabilizing nonbiological colloidal dispersions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1074-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-83
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers.
pubmed:affiliation
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA.
pubmed:publicationType
Journal Article