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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-5-28
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pubmed:databankReference |
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pubmed:abstractText |
The emergence of resistance to vancomycin, the drug of choice against methicillin-resistant Staphylococcus aureus, in enterococci has increased the need for new antibiotics. As chemical modification of the antibiotic structure is not trivial, we have initiated studies towards enzymatic modification by sequencing the DNA coding for the biosynthesis of chloroeremomycin (also known as A82846B and LY264826).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1074-5521
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-62
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:9545426-Actinobacteria,
pubmed-meshheading:9545426-Anti-Bacterial Agents,
pubmed-meshheading:9545426-Bacteria,
pubmed-meshheading:9545426-Chlorine,
pubmed-meshheading:9545426-DNA, Bacterial,
pubmed-meshheading:9545426-Genes, Bacterial,
pubmed-meshheading:9545426-Glycosyltransferases,
pubmed-meshheading:9545426-Molecular Sequence Data,
pubmed-meshheading:9545426-Open Reading Frames,
pubmed-meshheading:9545426-Oxidation-Reduction,
pubmed-meshheading:9545426-Protein Conformation,
pubmed-meshheading:9545426-Vancomycin
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pubmed:year |
1998
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pubmed:articleTitle |
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
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pubmed:affiliation |
Cambridge Centre for Molecular Recognition, Department of Chemistry, Cambridge, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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