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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1998-5-4
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pubmed:abstractText |
A series of 5-keto-substituted 7-tert-buty1-2,3-dihydro-3,3- dimethylbenzofurans (DHDMBFs) were found to be nonsteroidal antiinflammatory and analgesic agents. These compounds are inhibitors of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX) with selectivity for the COX-2 isoform. A series of analogues were prepared to investigate the scope of this lead. Five ketone side chains from active DHDMBFs were used to investigate the effects of changes in the DHDMBF "core": the size and identity of the heterocycle and the substituent requirements of the heterocycle and phenyl ring. Biological testing showed that a variety of structural changes can be accommodated, but no structure was clearly superior to the DHDMBF structure.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:DobsonR LRL,
pubmed-author:EichholdT HTH,
pubmed-author:EnzweilerKK,
pubmed-author:GayGG,
pubmed-author:GreenS ASA,
pubmed-author:JanuszJ MJM,
pubmed-author:JohnsonC RCR,
pubmed-author:KellsteinD EDE,
pubmed-author:KuhlenbeckD LDL,
pubmed-author:MagrissoI JIJ,
pubmed-author:McDow-DunhamK LKL,
pubmed-author:PikusJJ,
pubmed-author:Rosario-JansenTT,
pubmed-author:ScherzM WMW,
pubmed-author:SenanayakeC BCB,
pubmed-author:TulichJ LJL,
pubmed-author:WehmeyerK RKR,
pubmed-author:WuL ILI,
pubmed-author:YoungP APA
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1124-37
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9544212-Analgesics,
pubmed-meshheading:9544212-Animals,
pubmed-meshheading:9544212-Anti-Inflammatory Agents,
pubmed-meshheading:9544212-Benzofurans,
pubmed-meshheading:9544212-Blood Platelets,
pubmed-meshheading:9544212-Carrageenan,
pubmed-meshheading:9544212-Cyclooxygenase Inhibitors,
pubmed-meshheading:9544212-Edema,
pubmed-meshheading:9544212-Humans,
pubmed-meshheading:9544212-Lipoxygenase Inhibitors,
pubmed-meshheading:9544212-Rats,
pubmed-meshheading:9544212-Rats, Inbred Lew,
pubmed-meshheading:9544212-Rats, Sprague-Dawley
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pubmed:year |
1998
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pubmed:articleTitle |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
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pubmed:affiliation |
Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45040, USA.
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pubmed:publicationType |
Journal Article
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