|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0025260,
umls-concept:C0072171,
umls-concept:C0228174,
umls-concept:C0311400,
umls-concept:C0439825,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1948023,
umls-concept:C2349975,
umls-concept:C2911692
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1998-5-20
|
|
pubmed:abstractText |
To evaluate efficacy, safety, metabolic and clinical effects of propentofylline in Alzheimer's disease (AD), a prospective, randomized, double-blind, placebo-controlled trial was performed in 30 patients with mild to moderate AD who underwent pretreatment and posttreatment 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography under resting conditions and during stimulation with an auditory memory paradigm. Twenty-eight subjects completed the 3-month study. The drug was well tolerated. In the active treatment group, a significant increase of cerebral metabolic response to the memory task was observed (multiple measurement ANOVA P = 0.02). The placebo group showed a significantly decline in the MMSE score (P = 0.02) while there was no change in the treatment group. This suggests a protective role for propentofylline in slowing the progression of AD.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
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pubmed:issn |
0022-510X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
21
|
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pubmed:volume |
154
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
76-82
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9543326-Acoustic Stimulation,
pubmed-meshheading:9543326-Adult,
pubmed-meshheading:9543326-Aged,
pubmed-meshheading:9543326-Aged, 80 and over,
pubmed-meshheading:9543326-Alzheimer Disease,
pubmed-meshheading:9543326-Analysis of Variance,
pubmed-meshheading:9543326-Brain,
pubmed-meshheading:9543326-Double-Blind Method,
pubmed-meshheading:9543326-Female,
pubmed-meshheading:9543326-Fluorine Radioisotopes,
pubmed-meshheading:9543326-Fluorodeoxyglucose F18,
pubmed-meshheading:9543326-Glucose,
pubmed-meshheading:9543326-Humans,
pubmed-meshheading:9543326-Male,
pubmed-meshheading:9543326-Memory,
pubmed-meshheading:9543326-Middle Aged,
pubmed-meshheading:9543326-Neuroprotective Agents,
pubmed-meshheading:9543326-Prospective Studies,
pubmed-meshheading:9543326-Psychometrics,
pubmed-meshheading:9543326-Tomography, Emission-Computed,
pubmed-meshheading:9543326-Xanthines
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Propentofylline enhances cerebral metabolic response to auditory memory stimulation in Alzheimer's disease.
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|
pubmed:affiliation |
Max-Planck-Institut für Neurologische Forschung und Universitätsklinik für Neurologie, Köln, Germany. ruediger.mielke@pet.mpin-koeln.mpg.de
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|
