Linked Life Data

9542958

Source:http://linkedlifedata.com/resource/pubmed/id/9542958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-5-20
pubmed:abstractText
The first reported human case of possible disseminated infection with the insect pathogen Metarrhizium anisopliae var. anisopliae, a fungus which has been used commercially for biocontrol of insects, is described. The patient, a 9-year-old boy, had a 5-year history of pre-B-cell acute lymphoblastic leukemia and had been on chemotherapy throughout this period. After 10 days of profound neutropenia, lesions consistent with ecthyma gangrenosum appeared on his arms and legs. M. anisopliae was grown from specimens from three separate sites, collected at different times over a period of 1 month: a skin biopsy, a swab from the base of a lesion, and the core of another skin lesion which spontaneously discharged. The initial skin biopsy also showed histological evidence of epidermal necrosis and dermal invasion with fungal hyphae. A computed-tomography (CT) scan of the chest demonstrated a lesion in the superior segment of the lower lobe of the left lung. A CT scan of the brain revealed a lesion in the left temporoparietal region of the brain, consistent with an abscess. Despite antifungal treatment including liposomal amphotericin and 5-flucytosine, the patient eventually died. The initial portal of entry is unknown, but hematogenous dissemination to the skin appears likely because of the multiple ecthymic lesions, and the appearances of the brain lesion on the CT scan are consistent with a hematogenous fungal abscess.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-1534693, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-1876464, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-2052978, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-7043379, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-7070839, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-7811856, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-7978724, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-8264889, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-8354655, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-8500479, http://linkedlifedata.com/resource/pubmed/commentcorrection/9542958-9402530
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1146-50
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Disseminated invasive infection due to Metarrhizium anisopliae in an immunocompromised child.
pubmed:affiliation
Department of Microbiology, Royal Alexandra Hospital for Children, Westmead, NSW, Australia.
pubmed:publicationType
Journal Article, Case Reports