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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-5-19
|
| pubmed:abstractText |
We studied 14 young people with newly diagnosed hemisphere tumors, aged from 3 to 20 years (average 10 years). All underwent surgery following MR imaging (MRI) and spectroscopy (MRS). The tumors studied were three glioblastomas, one each of ganglio-glioblastoma, primitive neuroectodermal tumor (PNET), rhabdoid teratoid tumor, pilocytic astrocytoma, ependymoma, anaplastic ependymoma, and gliomatosis cerebri, and four gangliogliomas. Four patients died; ten patients are alive (five with stable residual tumor, five with no evident tumor). Images and spectra were acquired on a 1.5-T imager. Proton MRS was performed before gadolinium injection in all but one case. Single-voxel techniques were utilized in all cases, using a spin-echo or STEAM sequence with a long echo time (135 or 270 ms). Peak areas of N-acetyl aspartate (NAA), choline (Cho), and creatine and phosphocreatine (Cr) were assessed. The NAA/Cho peak-area ratio was very low in the patients who died (mean +/- s.d. 0.20 +/- 0.14), and higher in the patients who are alive (0.74 +/- 0.47; P = 0.007 by two-tailed t-test). The Cr/Cho peak-area ratio also followed a similar trend for the two groups (mean +/- s.d. 0.17 +/- 0.07 and 0.49 +/- 0.30, respectively; P = 0.01 by two-tailed t-test).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0028-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
121-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9541923-Brain,
pubmed-meshheading:9541923-Brain Neoplasms,
pubmed-meshheading:9541923-Child,
pubmed-meshheading:9541923-Female,
pubmed-meshheading:9541923-Humans,
pubmed-meshheading:9541923-Magnetic Resonance Imaging,
pubmed-meshheading:9541923-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9541923-Male,
pubmed-meshheading:9541923-Predictive Value of Tests,
pubmed-meshheading:9541923-Prognosis
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Prognostic value of proton MR spectroscopy of cerebral hemisphere tumors in children.
|
| pubmed:affiliation |
Department of Neuroradiology & Vascular Radiology, Hôpital de la Timone, Marseille, France.
|
| pubmed:publicationType |
Journal Article
|