Linked Life Data

9541251

Source:http://linkedlifedata.com/resource/pubmed/id/9541251

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-5-29
pubmed:abstractText
The periodontal ligament and dental pulp connective tissues are foetal-like, and their process of ageing may therefore differ from other tissues of mesenchymal origin. Several studies have already highlighted the lack of age changes in the extracellular matrix (ECM), but more needs to be known about cellular changes. For this study, tissues from the first molar teeth of Wistar rats aged 12 wk and 104 wk were compared by immunolocalisation of cytoskeletal components. Tissues from the first molar were immunostained, employing a panel of 16 monoclonal antibodies against cytokeratins, vimentin, F-actin and tubulin. Within the pulp, labelling for vimentin in both odontoblasts and pulpal fibroblasts and F-actin in the cell processes of odontoblasts was detected at both ages but with marked reduction in labelling in the older tissue. Within the periodontal ligament, vimentin labelling was weaker in the aged tissue, especially nearer the cementum. More significantly, the fibroblasts of the aged periodontal ligament expressed cytokeratin 19. In contrast to reports of little age change to the ECM, the cells of the pulp, and particularly the periodontal ligament, show marked changes to their cytoskeletal components.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0909-8836
pubmed:author
pubmed:issnType
Print
pubmed:volume
106 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
376-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Changes in the cytoskeleton of cells within the periodontal ligament and dental pulp of the rat first molar tooth during ageing.
pubmed:affiliation
Anatomy Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, UK. moxham@cardiff.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't