Linked Life Data

953984

Source:http://linkedlifedata.com/resource/pubmed/id/953984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1976-11-1
pubmed:abstractText
Several bacteriocins, bacterial proteinaceous antibiotics, are shown to markedly inhibit the division of various established (neoplastic) mammalian cell lines. The bacteriocins tested originated from Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, and Vibrio eltor. Using exponentially growing L60T mouse fibroblasts, the inhibitory effect was concentration dependent, and a growth inhibitory unit, equivalent to cytotoxic index 50, was established. Expression of toxicity as a function of duration of exposure to pyocin required 3 to 4 hr. DNA synthesis was inhibited and reflected the effects on growth inhibition. Maximal sensitivity to the bacteriocin was observed prior to mitosis in the G2 phase of the cell cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3561-7
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Bacterial proteinaceous products (bacteriocins) as cytotoxic agents of neoplasia.
pubmed:publicationType
Journal Article