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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1998-5-13
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pubmed:abstractText |
Interaction of the alpha beta T cell receptor (TCR) with major histocompatibility (MHC) molecules occupied with any of a large collection of peptides derived from self proteins is a critical step in driving T cell "positive" selection in the thymus. Interaction with this same pool of self-peptide/MHC ligands deletes T cells with potential self-reactivity. To examine how T cells survive both of these processes to form a self-tolerant mature repertoire, mice were constructed whose entire class II MHC IEk specific repertoire was positively selected on a single peptide covalently attached to the IEk molecule. In these mice T cells were identified that could respond to a variant of the positively selecting peptide bound to IEk. The affinities of the TCRs from these T cells for the positively selecting ligand were extremely low and at least 10-fold less than those for the activating ligand. These results support the theory that positive selection is driven by TCR affinities lower than those involved in T cell deletion or activation and that, if present at high concentration, even very low affinity ligands can positively select.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1315417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1319610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1617724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1656276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1739971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1832488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-1833816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-2467936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-2778316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-302918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-305459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-3260350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-3553374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-6194226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-6606682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-7648392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-7809136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-7889394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8052850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8078904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8124708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8128249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8177320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8183371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8245790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8419174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8496675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8598039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8637599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8758894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-8955273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-9005856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-9166421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-9348301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9539770-9391114
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4522-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9539770-Amino Acid Sequence,
pubmed-meshheading:9539770-Asparagine,
pubmed-meshheading:9539770-Base Sequence,
pubmed-meshheading:9539770-Clonal Anergy,
pubmed-meshheading:9539770-Codon,
pubmed-meshheading:9539770-Cysteine,
pubmed-meshheading:9539770-Histocompatibility Antigens Class II,
pubmed-meshheading:9539770-Hybridomas,
pubmed-meshheading:9539770-Interleukin-2,
pubmed-meshheading:9539770-Kinetics,
pubmed-meshheading:9539770-Molecular Sequence Data,
pubmed-meshheading:9539770-Peptide Fragments,
pubmed-meshheading:9539770-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9539770-Restriction Mapping,
pubmed-meshheading:9539770-T-Lymphocytes
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pubmed:year |
1998
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pubmed:articleTitle |
T cell positive selection by a high density, low affinity ligand.
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pubmed:affiliation |
Howard Hughes Medical Institute, Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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