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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-6-15
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pubmed:abstractText |
There is increasing evidence that a dysfunction of the dopaminergic system may be involved in the pathogenesis of idiopathic dystonia. To visualize possible alterations of the pre- and postsynaptic side of striatal dopaminergic synapses, SPECT studies using the radiotracers [123I] epidepride and [123I] beta-CIT were performed in 10 patients with idiopathic cervical dystonia. Eleven age- and sex-matched subjects served as controls. [123I] Epidepride is a new highly affine marker of D2 receptors, and [123I] beta-CIT binds to dopamine transporters on dopaminergic nerve endings. [123I] Epidepride binding was significantly reduced in both striata of dystonia patients compared with controls (p < 0.05). In contrast, striatal [123I beta-CIT uptake did not differ from controls. We conclude that dopaminergic dysfunction in idiopathic focal dystonia mainly involves postsynaptic mechanisms and suggest a disturbance of the indirect pathway of the motor circuit resulting in a disinhibited thalamocortical stimulation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzamides,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Contrast Media,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Plasma Membrane Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/RTI 55,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/epidepride
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0885-3185
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-23
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9539347-Adult,
pubmed-meshheading:9539347-Aged,
pubmed-meshheading:9539347-Benzamides,
pubmed-meshheading:9539347-Brain Mapping,
pubmed-meshheading:9539347-Carrier Proteins,
pubmed-meshheading:9539347-Cocaine,
pubmed-meshheading:9539347-Contrast Media,
pubmed-meshheading:9539347-Corpus Striatum,
pubmed-meshheading:9539347-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:9539347-Dystonia Musculorum Deformans,
pubmed-meshheading:9539347-Female,
pubmed-meshheading:9539347-Humans,
pubmed-meshheading:9539347-Iodine Radioisotopes,
pubmed-meshheading:9539347-Male,
pubmed-meshheading:9539347-Membrane Glycoproteins,
pubmed-meshheading:9539347-Membrane Transport Proteins,
pubmed-meshheading:9539347-Middle Aged,
pubmed-meshheading:9539347-Nerve Net,
pubmed-meshheading:9539347-Nerve Tissue Proteins,
pubmed-meshheading:9539347-Pyrrolidines,
pubmed-meshheading:9539347-Receptors, Dopamine,
pubmed-meshheading:9539347-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:9539347-Torticollis
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pubmed:year |
1998
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pubmed:articleTitle |
Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT.
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pubmed:affiliation |
Department of Neurology, Bayerische Julius-Maximilians-Universität Würzburg, Germany.
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pubmed:publicationType |
Journal Article
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