| pubmed-article:9539309 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0039748 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0033308 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0018061 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C1819436 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9539309 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9539309 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9539309 | pubmed:dateCreated | 1998-4-20 | lld:pubmed |
| pubmed-article:9539309 | pubmed:abstractText | Increasing evidence suggests that cytokines may play a role in ovarian processes. The purpose of this study was to determine if interleukin-1 (IL-1) could modulate rabbit pre-ovulatory follicular function and to explore cellular sites of IL-1 biosynthesis in rabbit follicles. Development of rabbit pre-ovulatory follicles was induced by 200 mIU equine chorionic gonadotropin daily for 2 days. Seventy-two hours after the last injection, ovaries were excised and granulosa and theca cells isolated. The two types of cell were pre-incubated for 24 h in Minimum Essential Medium (MEM) with 5% fetal calf serum (FCS), and then incubated for 24 h in MEM with 2.5% FCS with appropriate stimulants. Results showed that rabbit granulosa and theca cell culture supernatants contain IL-1 bioactivity and that this bioactivity was diminished by gonadotropins, FSH and human chorionic gonadotropin, in a dose-dependent manner. Low doses of IL-1 (1 ng/ml) inhibited gonadotropin-induced progesterone production in both cell types and at the same time increased cell numbers. A study of the mechanism of IL-1 action demonstrated that it affects cAMP generation, and also steps distal to cAMP formation. We conclude that in our model gonadotropins, by inhibiting IL-1 production, could control IL-1 modulation of gonadotropin action on steroidogenesis. | lld:pubmed |
| pubmed-article:9539309 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9539309 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9539309 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9539309 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9539309 | pubmed:issn | 0804-4643 | lld:pubmed |
| pubmed-article:9539309 | pubmed:author | pubmed-author:LeymariePP | lld:pubmed |
| pubmed-article:9539309 | pubmed:author | pubmed-author:BenhaïmAA | lld:pubmed |
| pubmed-article:9539309 | pubmed:author | pubmed-author:FéralCC | lld:pubmed |
| pubmed-article:9539309 | pubmed:author | pubmed-author:DelarueBB | lld:pubmed |
| pubmed-article:9539309 | pubmed:author | pubmed-author:BréardEE | lld:pubmed |
| pubmed-article:9539309 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9539309 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:9539309 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9539309 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9539309 | pubmed:pagination | 328-36 | lld:pubmed |
| pubmed-article:9539309 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:meshHeading | pubmed-meshheading:9539309-... | lld:pubmed |
| pubmed-article:9539309 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9539309 | pubmed:articleTitle | Inhibition by gonadotropins of interleukin-1 production by rabbit granulosa and theca cells: effects on gonadotropin-induced progesterone production. | lld:pubmed |
| pubmed-article:9539309 | pubmed:affiliation | Laboratoire de Biochimie, EP 9 CNRS, IBBA Université de Caen, CHU C ote de Nacre, France. | lld:pubmed |
| pubmed-article:9539309 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9539309 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9539309 | lld:pubmed |
