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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-4-23
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pubmed:abstractText |
Spontaneous neuronal activity plays an important role in the development of cortical circuitry, yet its spatio-temporal dynamics are poorly understood. Cajal-Retzius (CR) neurons in developing layer 1 are necessary for correct cortical lamination and are strategically located to coordinate early circuit activity. To characterize the spontaneous activity of CR and other layer 1 neurons during cortical development, we imaged calcium transients in populations of layer 1 neurons in hemispheres and slices from postnatal rat somato-sensory neocortex. The spontaneous activity in layer 1 had complex spatio-temporal patterns. Groups of non-CR cells showed synchronous activations and formed networks of correlated neurons superimposed in the same territory. Correlated activity among non-CR cells was mediated by a depolarizing effect of GABA and was modulated by glutamate, probably released by CR cells. Our findings demonstrate that developing layer 1 can sustain complex patterns of correlated activity and reveal a circuit mechanism that can mediate this patterned activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/GABA Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Muscimol,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9539127-Acetylcholine,
pubmed-meshheading:9539127-Adrenergic alpha-Agonists,
pubmed-meshheading:9539127-Animals,
pubmed-meshheading:9539127-Calcium,
pubmed-meshheading:9539127-Cerebral Cortex,
pubmed-meshheading:9539127-Electric Stimulation,
pubmed-meshheading:9539127-Excitatory Amino Acid Agonists,
pubmed-meshheading:9539127-GABA Agonists,
pubmed-meshheading:9539127-Glutamic Acid,
pubmed-meshheading:9539127-Muscimol,
pubmed-meshheading:9539127-N-Methylaspartate,
pubmed-meshheading:9539127-Neurons,
pubmed-meshheading:9539127-Neurotransmitter Agents,
pubmed-meshheading:9539127-Norepinephrine,
pubmed-meshheading:9539127-Organ Culture Techniques,
pubmed-meshheading:9539127-Patch-Clamp Techniques,
pubmed-meshheading:9539127-Rats,
pubmed-meshheading:9539127-Rats, Sprague-Dawley,
pubmed-meshheading:9539127-Synaptic Transmission,
pubmed-meshheading:9539127-Tetrodotoxin,
pubmed-meshheading:9539127-Time Factors,
pubmed-meshheading:9539127-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid,
pubmed-meshheading:9539127-gamma-Aminobutyric Acid
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pubmed:year |
1998
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pubmed:articleTitle |
Networks of coactive neurons in developing layer 1.
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pubmed:affiliation |
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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