| pubmed-article:9538129 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0441471 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0205422 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:9538129 | lifeskim:mentions | umls-concept:C0522498 | lld:lifeskim |
| pubmed-article:9538129 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9538129 | pubmed:dateCreated | 1998-6-2 | lld:pubmed |
| pubmed-article:9538129 | pubmed:abstractText | Mutations of the transforming growth factor-beta type II receptor (TGF-beta RII) gene have been detected in several human cancers. However, mutation analysis of coding sequences of TGF-beta RII in gastric carcinomas has not yet been fully elucidated. We performed PCR-SSCP analysis and direct DNA sequencing of the entire coding region of TGF- RII in 38 human sporadic gastric cancers and 8 gastric cancer cell lines. Mutations of the TGF-beta RII were detected in two tumors and three cell lines. Two tumors had one base deletion in the polyadenine tract in exon 3, the cystein-rich extracellular domain. Three cell lines had a silent mutation in the kinase domain located in exon 4. Polymorphisms were detected in introns 2 and 3. An a/g polymorphism was observed at the seventh base in intron 2 and an a/t polymorphism was observed at the fourth to last base in intron 3. There were no mutations in exons 1, 2, 5, 6 and 7. These results indicate that the polyadenine tract in the TGF-beta RII is a mutational hot spot in human gastric cancer. However, these results also suggest that mutations of the gene are rare events in human sporadic gastric cancer. | lld:pubmed |
| pubmed-article:9538129 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9538129 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538129 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9538129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9538129 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9538129 | pubmed:month | May | lld:pubmed |
| pubmed-article:9538129 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:NagamachiYY | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:TaharaEE | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:TakenoshitaSS | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:YasueSS | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:YokozakiHH | lld:pubmed |
| pubmed-article:9538129 | pubmed:author | pubmed-author:ShitaraYY | lld:pubmed |
| pubmed-article:9538129 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9538129 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9538129 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9538129 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9538129 | pubmed:pagination | 1061-5 | lld:pubmed |
| pubmed-article:9538129 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:meshHeading | pubmed-meshheading:9538129-... | lld:pubmed |
| pubmed-article:9538129 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9538129 | pubmed:articleTitle | Mutation of the transforming growth factor-beta type II receptor gene is a rare event in human sporadic gastric carcinomas. | lld:pubmed |
| pubmed-article:9538129 | pubmed:affiliation | First Department of Pathology, Hiroshima University School of Medicine, Hiroshima 734-8551, Japan. | lld:pubmed |
| pubmed-article:9538129 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9538129 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9538129 | lld:pubmed |
