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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1998-4-21
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pubmed:databankReference |
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pubmed:abstractText |
TRAIL/Apo-2L induces rapid apoptosis of a variety of tumor cell lines. A family of tumor necrosis factor receptor-related molecules have been identified as receptors for TRAIL. Herein, we report the identification of another member of the TRAIL receptor family, TRUNDD (TRAIL receptor with a truncated death domain). The TRUNDD transcript was detected in multiple human tissues. TRUNDD is highly homologous to all known TRAIL receptors and has an extracellular TRAIL-binding domain but lacks a functional intracellular death domain and does not induce apoptosis. Consistent with an inhibitory role, ectopic expression of TRUNDD attenuated TRAIL-induced apoptosis in mammalian cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
424
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9537512-Amino Acid Sequence,
pubmed-meshheading:9537512-Apoptosis,
pubmed-meshheading:9537512-Apoptosis Regulatory Proteins,
pubmed-meshheading:9537512-Cells, Cultured,
pubmed-meshheading:9537512-Humans,
pubmed-meshheading:9537512-Membrane Glycoproteins,
pubmed-meshheading:9537512-Membrane Proteins,
pubmed-meshheading:9537512-Molecular Sequence Data,
pubmed-meshheading:9537512-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:9537512-Sequence Alignment,
pubmed-meshheading:9537512-Sequence Homology, Amino Acid,
pubmed-meshheading:9537512-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:9537512-Tissue Distribution,
pubmed-meshheading:9537512-Tumor Necrosis Factor Decoy Receptors,
pubmed-meshheading:9537512-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling.
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pubmed:affiliation |
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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