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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-4-23
|
| pubmed:abstractText |
Familial combined hyperlipidaemia (FCHL) is a common, multifactorial disorder associated with elevated levels of plasma triglyceride, cholesterol, or both. A characteristic feature is increased secretion of very low density lipoproteins (VLDL) and apolipoprotein B (apoB). Although FCHL is the most common cause of premature coronary artery disease (CAD), accounting for over 10% of cases, its aetiology remains largely unknown. One powerful approach to the dissection of complex genetic traits involves the use of animal models. We have identified a mouse strain, HcB-19/Dem (HcB-19), which exhibits hypertriglyceridaemia, hypercholesterolaemia and elevated levels of plasma apoB. Like FCHL patients, HcB-19 mice also exhibit increased secretion of triglyceride-rich lipoproteins, and their hyperlipidaemia becomes progressively more severe with age. It is likely that the hyperlipidaemia results from a mutation of a novel gene that arose during development of strain HcB-19. We mapped the hyperlipidaemia gene (Hyplip1) to the distal portion of mouse chromosome 3. This region is syntenic to human chromosome 1q21-q23, which has recently been shown to harbour a gene associated with FCHL in families from a Finnish isolate.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1061-4036
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
374-7
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9537422-Age Factors,
pubmed-meshheading:9537422-Animals,
pubmed-meshheading:9537422-Cholesterol,
pubmed-meshheading:9537422-Cholesterol, HDL,
pubmed-meshheading:9537422-Cholesterol, VLDL,
pubmed-meshheading:9537422-Chromosome Mapping,
pubmed-meshheading:9537422-Chromosomes,
pubmed-meshheading:9537422-Chromosomes, Human, Pair 1,
pubmed-meshheading:9537422-Female,
pubmed-meshheading:9537422-Genes,
pubmed-meshheading:9537422-Genetic Linkage,
pubmed-meshheading:9537422-Humans,
pubmed-meshheading:9537422-Hyperlipidemias,
pubmed-meshheading:9537422-Male,
pubmed-meshheading:9537422-Mice,
pubmed-meshheading:9537422-Mice, Inbred C3H,
pubmed-meshheading:9537422-Mice, Inbred C57BL,
pubmed-meshheading:9537422-Mice, Inbred Strains,
pubmed-meshheading:9537422-Mice, Mutant Strains,
pubmed-meshheading:9537422-Microsatellite Repeats,
pubmed-meshheading:9537422-Species Specificity,
pubmed-meshheading:9537422-Triglycerides
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Mapping a gene for combined hyperlipidaemia in a mutant mouse strain.
|
| pubmed:affiliation |
Department of Medicine, University of California, Los Angeles 90095, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|