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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-4-21
|
| pubmed:abstractText |
Thrombospondin-1 (TSP-1) is important in platelet adhesion and aggregation, inflammation, cell to cell interaction, angiogenesis, and smooth muscle cell (SMC) proliferation. TSP-1 expression increases rapidly with injury. Therefore, we hypothesize that TSP-1 may play a role in the development of intimal hyperplasia (IH). The purpose of this study is to examine the interaction between cholesterol and TSP-1 on SMC proliferation and to quantitatively assess TSP-1 expression in an established model of IH, with and without underlying cholesterol-induced atherosclerosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
11-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9536966-Animals,
pubmed-meshheading:9536966-Arteriosclerosis,
pubmed-meshheading:9536966-Cell Division,
pubmed-meshheading:9536966-Cells, Cultured,
pubmed-meshheading:9536966-Disease Models, Animal,
pubmed-meshheading:9536966-Hypercholesterolemia,
pubmed-meshheading:9536966-Hyperplasia,
pubmed-meshheading:9536966-Male,
pubmed-meshheading:9536966-Muscle, Smooth, Vascular,
pubmed-meshheading:9536966-Platelet-Derived Growth Factor,
pubmed-meshheading:9536966-Rabbits,
pubmed-meshheading:9536966-Thrombospondin 1
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Thrombospondin-1 is elevated with both intimal hyperplasia and hypercholesterolemia.
|
| pubmed:affiliation |
Department of Surgery, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania, USA.
|
| pubmed:publicationType |
Journal Article
|