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rdf:type |
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lifeskim:mentions |
umls-concept:C0019693,
umls-concept:C0085358,
umls-concept:C0149678,
umls-concept:C0205164,
umls-concept:C0205178,
umls-concept:C0205191,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515021,
umls-concept:C1706438,
umls-concept:C1707391,
umls-concept:C1707455,
umls-concept:C2698600
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pubmed:issue |
4
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pubmed:dateCreated |
1998-4-21
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pubmed:abstractText |
CD8+ lymphocyte phenotypes were characterized during acute Epstein-Barr virus (EBV) infection, and a comparison was made to previous studies of human immunodeficiency virus (HIV). This was of interest because CD8+ cells contribute to immunologic control of both infections, but the usual outcome of EBV infection is benign, whereas untreated HIV infection is fatal. During acute EBV infection, CD8+ cells expressed elevated levels of the activation antigens CD38 and HLA-DR, similar to that during chronic HIV infection. Within 16 weeks, when EBV latency is established, CD8+ cell activation had resolved. In contrast, activation persists in HIV infection. Expression of CD38 and HLA-DR on CD8+ cells could be a marker for ongoing viral replication in both infections. Other CD8+ cell alterations observed in this study of acute EBV infection included increases in both CD62L- and CD62L+ CD8+ cells and unique kinetics in the expansion of the CD57+CD8+ cell subset.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD57,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/L-Selectin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9534988-ADP-ribosyl Cyclase,
pubmed-meshheading:9534988-Adolescent,
pubmed-meshheading:9534988-Adult,
pubmed-meshheading:9534988-Antigens, CD,
pubmed-meshheading:9534988-Antigens, CD38,
pubmed-meshheading:9534988-Antigens, CD57,
pubmed-meshheading:9534988-Antigens, Differentiation,
pubmed-meshheading:9534988-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9534988-Female,
pubmed-meshheading:9534988-Flow Cytometry,
pubmed-meshheading:9534988-HIV Infections,
pubmed-meshheading:9534988-HLA-DR Antigens,
pubmed-meshheading:9534988-Herpesvirus 4, Human,
pubmed-meshheading:9534988-Humans,
pubmed-meshheading:9534988-Infectious Mononucleosis,
pubmed-meshheading:9534988-L-Selectin,
pubmed-meshheading:9534988-Lymphocyte Activation,
pubmed-meshheading:9534988-Male,
pubmed-meshheading:9534988-Membrane Glycoproteins,
pubmed-meshheading:9534988-NAD+ Nucleosidase,
pubmed-meshheading:9534988-T-Lymphocyte Subsets,
pubmed-meshheading:9534988-Time Factors,
pubmed-meshheading:9534988-Virus Latency,
pubmed-meshheading:9534988-Virus Replication
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pubmed:year |
1998
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pubmed:articleTitle |
Major expansions of select CD8+ subsets in acute Epstein-Barr virus infection: comparison with chronic human immunodeficiency virus disease.
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pubmed:affiliation |
Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095-1745, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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