Linked Life Data

9533811

Source:http://linkedlifedata.com/resource/pubmed/id/9533811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-5-13
pubmed:abstractText
The ob gene encodes a protein, which regulates satiety, metabolic rate and fat storage. The administration of a pool of five 20-amino-acid fragment peptides derived from the carboxy-terminal region of the ob protein produced a statistically significant reduction in body weight gain in adult rats, while rectal temperature showed a statistically significant increase. Administration of the same pool of peptides to young rats did not produce changes in body weight gain, although a statistically significant transient increase in rectal temperature was observed. These results envisage the possibility that small sequences of amino acids derived from the ob protein may mimic the effects of the whole protein on temperature and ponderal regulation. Furthermore, data suggest possible age-related differences in the response to leptin administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0167-0115
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Age-related differences in the thermogenic and ponderal effects following the administration of fragment peptides from the rat ob protein.
pubmed:affiliation
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't