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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-4-15
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pubmed:abstractText |
Several recent studies have reported different associations between HLA specificities and human papillomavirus (HPV)-associated disease of the cervix. We report the distribution of DQA1 and DQB1 genes and HPV infection in a population-based case-control study including 92 patients with histologically verified cervical intraepithelial neoplasia grade II-III (CIN II-III) (thus including moderate and severe dysplasia and carcinoma in situ) and 225 control subjects. We found an overrepresentation of the DQA1*0102-DQB1*0602 haplotype among HPV-positive cases compared with controls. The association was even stronger when comparing HPV-16-positive cases with HPV-16-positive controls. In addition, among HPV-16-positive individuals, we observed a decreased frequency of DQA1*0102-DQB1*0604 in cases compared with controls. We were not able to detect any association between CIN II-III and DQB1*03. Compared with previous findings in cervical cancer, our data indicate that carrying the DQA1*0102-DQB1*0602 haplotype gives an increased risk of developing CIN when infected with HPV-16, without influencing progression to cancer.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0020-7136
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
30
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pubmed:volume |
76
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
19-24
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:9533756-Adult,
pubmed-meshheading:9533756-Carcinoma in Situ,
pubmed-meshheading:9533756-Case-Control Studies,
pubmed-meshheading:9533756-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:9533756-Female,
pubmed-meshheading:9533756-HLA-D Antigens,
pubmed-meshheading:9533756-Haplotypes,
pubmed-meshheading:9533756-Humans,
pubmed-meshheading:9533756-Norway,
pubmed-meshheading:9533756-Papillomaviridae,
pubmed-meshheading:9533756-Papillomavirus Infections,
pubmed-meshheading:9533756-Risk Factors,
pubmed-meshheading:9533756-Uterine Cervical Neoplasms
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pubmed:year |
1998
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pubmed:articleTitle |
An increased risk of cervical intra-epithelial neoplasia grade II-III among human papillomavirus positive patients with the HLA-DQA1*0102-DQB1*0602 haplotype: a population-based case-control study of Norwegian women.
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pubmed:affiliation |
Department of Genetics, Institute of Cancer Research, the Norwegian Radiumhospital, Oslo.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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