Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-5-4
pubmed:abstractText
Twenty-seven patients with acute monosymptomatic optic neuritis were randomly selected from a population-based cohort of patients extensively screened for known etiologies of ON. Paired serum and CSF obtained median 20 days from onset were examined for oligoclonal IgG, free kappa and free lambda chains, and virus-specific oligoclonal IgG antibodies by an affinity-mediated capillary blot technique. CSF-restricted oligoclonal IgG bands, free kappa and free lambda chain bands were observed in 17, 15 and nine patients, respectively. In addition, 16 patients showed a polyspecific intrathecal synthesis of oligoclonal IgG antibodies against one or more viruses (12 measles, nine varicella zoster, six rubella, six mumps) compared to all the 18 examined patients with definite multiple sclerosis (P = 0.0014). The presence of virus-specific oligoclonal IgG was significantly related to the results of oligoclonal IgG (P = 0.0034), free kappa chain bands (P = 0.0020), and brain MRI abnormalities (P = 0.0402). At 1 year follow-up five patients had developed clinically definite multiple sclerosis; all had virus-specific oligoclonal IgG antibodies, oligoclonal IgG and abnormal MRI at onset.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1352-4585
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
22-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9532588-Adult, pubmed-meshheading:9532588-Antibodies, Viral, pubmed-meshheading:9532588-Antibody Specificity, pubmed-meshheading:9532588-Brain, pubmed-meshheading:9532588-Cohort Studies, pubmed-meshheading:9532588-Female, pubmed-meshheading:9532588-Follow-Up Studies, pubmed-meshheading:9532588-Herpes Zoster, pubmed-meshheading:9532588-Humans, pubmed-meshheading:9532588-Immunoglobulin G, pubmed-meshheading:9532588-Immunoglobulin kappa-Chains, pubmed-meshheading:9532588-Immunoglobulin lambda-Chains, pubmed-meshheading:9532588-Magnetic Resonance Imaging, pubmed-meshheading:9532588-Male, pubmed-meshheading:9532588-Measles virus, pubmed-meshheading:9532588-Middle Aged, pubmed-meshheading:9532588-Multiple Sclerosis, pubmed-meshheading:9532588-Mumps virus, pubmed-meshheading:9532588-Optic Neuritis, pubmed-meshheading:9532588-Rubella virus, pubmed-meshheading:9532588-Spinal Puncture
pubmed:year
1998
pubmed:articleTitle
Intrathecal synthesis of virus-specific oligoclonal IgG, and of free kappa and free lambda oligoclonal bands in acute monosymptomatic optic neuritis. Comparison with brain MRI.
pubmed:affiliation
Department of Neurology, Glostrup University Hospital, Denmark.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't