Linked Life Data

9532528

Source:http://linkedlifedata.com/resource/pubmed/id/9532528

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-5-14
pubmed:abstractText
The objective of this work was to evaluate the ability of appropriate silicone elastomers to encapsulate hydrophilic compounds in microspheres prepared according to a multiphase emulsion-polymerization process. The particle size of the microspheres can be modified by controlling the usual emulsification parameters, such as the viscosity of the different phases, shear rates and surface activity properties of additives. The encapsulation efficiencies of a hydrophilic drug, propranolol hydrochloride, were very high but its release rates were very slow. Osmotic agents such as glycerol and propylene glycol did not enhance the release rate, whereas it was slightly increased by both sodium chloride addition and higher drug loading.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0265-2048
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-36
pubmed:dateRevised
2009-7-21
pubmed:meshHeading
pubmed:articleTitle
Preparation of silicone microspheres by emulsion polymerization: application to the encapsulation of a hydrophilic drug.
pubmed:affiliation
Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Galénique et Biopharmacie, Université de Nancy I, France.
pubmed:publicationType
Journal Article