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| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C0037018 | lld:lifeskim |
| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C1424685 | lld:lifeskim |
| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C0205246 | lld:lifeskim |
| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9531314 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:9531314 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9531314 | pubmed:dateCreated | 1998-4-21 | lld:pubmed |
| pubmed-article:9531314 | pubmed:abstractText | IL-12 (or LPS) priming and subsequent challenge by LPS produces the generalized Shwartzman reaction. IFN-gamma induced by IL-12 is a crucial cytokine in the priming phase. In vivo depletion of both NK cells and NK1+ alphabeta T cells of mice by anti-NK1.1 Ab greatly reduced the elevation of serum IFN-gamma induced by IL-12 and significantly reduced mortality after subsequent injection of LPS, whereas depletion of NK cells alone by anti-asialo GM1 Ab only partially decreased serum IFN-gamma, and lethality was not changed. Cell sorting and culture experiments confirmed that liver NK1+ alphabeta T cells of IL-12-injected mice produced greater amounts of IFN-gamma than did liver NK cells. MHC class I-deficient mice of C57BL/6 background, which lack a majority of NK1+ alphabeta T cells, produced low amounts of IFN-gamma by IL-12; no mortality was observed after the LPS challenge. However, production of TNF-alpha in the second phase (after LPS challenge) was not inhibited by depletion of NK cells alone or both subsets. IL-12 and subsequent LPS challenge activated NK1+ alphabeta T cells in the liver and induced strong cytotoxicity of these cells not only against tumor cells (including Fas-negative tumors) but also against a syngeneic hepatocyte cell line. Our findings show that IFN-gamma produced by NK1+ alphabeta T cells is essential for the IL-12 priming of the Shwartzman reaction, and the autoreactivity of NK1+ alphabeta T cells in the liver is involved in the hepatic disorders that are sometimes caused by IL-12, LPS, or the generalized Shwartzman reaction. | lld:pubmed |
| pubmed-article:9531314 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9531314 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9531314 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9531314 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9531314 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9531314 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:TakedaKK | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:SatohMM | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:TakadaHH | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:SekiSS | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:KumagaiKK | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:ObinataMM | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:YanaiNN | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:OgasawaraKK | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:HashimotoWW | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:OkuyamaRR | lld:pubmed |
| pubmed-article:9531314 | pubmed:author | pubmed-author:HiraideHH | lld:pubmed |
| pubmed-article:9531314 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9531314 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9531314 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:9531314 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9531314 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9531314 | pubmed:pagination | 3522-7 | lld:pubmed |
| pubmed-article:9531314 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9531314 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9531314 | pubmed:articleTitle | Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction. | lld:pubmed |
| pubmed-article:9531314 | pubmed:affiliation | Department of Microbiology, Tohoku University School of Dentistry, Sendai, Japan. | lld:pubmed |
| pubmed-article:9531314 | pubmed:publicationType | Journal Article | lld:pubmed |
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