| pubmed-article:9528779 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C0666728 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C2675940 | lld:lifeskim |
| pubmed-article:9528779 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:9528779 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9528779 | pubmed:dateCreated | 1998-5-21 | lld:pubmed |
| pubmed-article:9528779 | pubmed:abstractText | Zeta-Crystallin is a taxon-specific crystallin, an enzyme which has undergone direct gene recruitment as a structural component of the guinea pig lens through a Pax6-dependent mechanism. Tissue specificity arises through a combination of effects involving three sites in the lens promoter. The Pax6 site (ZPE) itself shows specificity for an isoform of Pax6 preferentially expressed in lens cells. High-level expression of the promoter requires a second site, identical to an alphaCE2 site or half Maf response element (MARE), adjacent to the Pax6 site. A promoter fragment containing Pax6 and MARE sites gives lens-preferred induction of a heterologous promoter. Complexes binding the MARE in lens nuclear extracts are antigenically related to Nrl, and cotransfection with Nrl elevates zeta-crystallin promoter activity in lens cells. A truncated zeta promoter containing Nrl-MARE and Pax6 sites has a high level of expression in lens cells in transgenic mice but is also active in the brain. Suppression of the promoter in the brain requires sequences between -498 and -385, and a site in this region forms specific complexes in brain extract. A three-level model for lens-specific Pax6-dependent expression and gene recruitment is suggested: (i) binding of a specific isoform of Pax6; (ii) augmentation of expression through binding of Nrl or a related factor; and (iii) suppression of promoter activity in the central nervous system by an upstream negative element in the brain but not in the lens. | lld:pubmed |
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| pubmed-article:9528779 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9528779 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9528779 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9528779 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9528779 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:9528779 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:LebAA | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:RichardsonJJ | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:MaasRR | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:SwaroopAA | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:WistowGG | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:Sharon-Frilin... | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:RauchmanMM | lld:pubmed |
| pubmed-article:9528779 | pubmed:author | pubmed-author:SperbeckSS | lld:pubmed |
| pubmed-article:9528779 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9528779 | pubmed:volume | 18 | lld:pubmed |
