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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1998-5-1
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pubmed:abstractText |
A 71-year-old woman underwent radical resection in May 1994 for a mediastinal mass invading the anterior chest wall. Histopathological examination revealed adenosquamous cell carcinoma. She was treated with postoperative chemotherapy including 5-fluorouracil (5-FU) and 4'-D-tetrahydropyrayl-doxorubicin (THP), based on in vitro chemosensitivity testing (CST), by MTT assay, using a surgical specimen. In December 1994, a recurrent tumor was detected on the left anterior chest wall and the patient received two courses of 5-FU, THP and methotrexate (MTX). The size of the chest-wall tumor decreased 25%. In July 1995, the patient had involvement of the left axillary lymph node and brain metastases in addition to the mass on the chest wall. Therefore, cisplatin, 5-FU and MTX were selected as treatment agents, based on CST using a metastatic axillary lymph node. After two courses of these agents, chest computed tomography showed a 91% reduction in the size of the chest wall tumor. Radiation was administered for the brain metastasis. In March 1997, the patient died of thymic carcinoma.
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pubmed:language |
jpn
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-5252
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9528232-Aged,
pubmed-meshheading:9528232-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9528232-Brain Neoplasms,
pubmed-meshheading:9528232-Carcinoma, Adenosquamous,
pubmed-meshheading:9528232-Cisplatin,
pubmed-meshheading:9528232-Combined Modality Therapy,
pubmed-meshheading:9528232-Drug Administration Schedule,
pubmed-meshheading:9528232-Drug Screening Assays, Antitumor,
pubmed-meshheading:9528232-Female,
pubmed-meshheading:9528232-Fluorouracil,
pubmed-meshheading:9528232-Humans,
pubmed-meshheading:9528232-Lymphatic Metastasis,
pubmed-meshheading:9528232-Methotrexate,
pubmed-meshheading:9528232-Neoplasm Recurrence, Local,
pubmed-meshheading:9528232-Thymus Neoplasms,
pubmed-meshheading:9528232-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
[Successful chemotherapy based on in vitro chemosensitivity testing in a case of recurrent thymic carcinoma].
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pubmed:affiliation |
First Department of Surgery, Kumamoto University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
English Abstract,
Case Reports
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