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pubmed-article:9525699pubmed:abstractTextAberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.lld:pubmed
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pubmed-article:9525699pubmed:dateRevised2005-11-16lld:pubmed
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pubmed-article:9525699pubmed:articleTitleLessons from TGF-beta transgenic mice.lld:pubmed
pubmed-article:9525699pubmed:affiliationDivision of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461-1602, USA. bottinge@aecom.yu.edulld:pubmed
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