Linked Life Data

9525342

Source:http://linkedlifedata.com/resource/pubmed/id/9525342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1998-6-10
pubmed:abstractText
Growth hormone (GH) and insulin-like growth factor I (IGF-I) deficiencies have been associated with osteopenia in both children and adults. To examine the effects of growth hormone resistance on bone mineral and body composition, we studied 11 adults (mean age 30 years) with growth hormone receptor deficiency (GHRD, Laron syndrome) and 11 age- and gender-matched controls from Southern Ecuador. Bone mineral and body composition were determined by dual-energy X-ray absorptiometry. Bone physiology was assessed with biochemical markers of bone turnover and dynamic bone histomorphometry. Bone size and body composition differed markedly between subjects with GHRD and controls. Affected adults were 40 cm shorter than controls, had significantly less lean body mass, and had increased percent body fat. Bone mineral content and density (BMD) at the spine, femoral neck, and whole body were significantly lower in adults with GHRD than in controls. Mean BMD Z scores were -1.5 to -1.6 at all sites in affected women and -2.2 to -2.3 in men with GHRD. Estimated volumetric bone density (BMAD) at the spine and femoral neck, however, was not reduced in GHRD. Spine BMAD was 0.210 +/- 0.025 versus 0.177 +/- 0.021 for affected women versus controls (p < 0.05) and 0.173 +/- 0.018 versus 0.191 +/- 0.025 for men with GHRD versus normals (p = 0.31). Urinary pyridinoline concentrations were significantly greater in adults with GHRD than in controls, while type I collagen C-telopeptide breakdown products and markers of bone formation did not differ. Differences in histomorphometry were limited to a reduction in trabecular connectivity; bone volume and formation rate were similar to controls. These data confirm the importance of the GH/IGF axis in regulating bone size and body composition. The contribution of these peptides to the acquisition and maintenance of bone mineral is less certain since volumetric bone density was preserved despite low levels of IGF-I and IGFBP-3 associated with GH resistance.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0884-0431
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-21
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9525342-Absorptiometry, Photon, pubmed-meshheading:9525342-Adult, pubmed-meshheading:9525342-Amino Acids, pubmed-meshheading:9525342-Body Composition, pubmed-meshheading:9525342-Body Height, pubmed-meshheading:9525342-Bone Density, pubmed-meshheading:9525342-Child, pubmed-meshheading:9525342-Cohort Studies, pubmed-meshheading:9525342-Ecuador, pubmed-meshheading:9525342-Female, pubmed-meshheading:9525342-Femur Neck, pubmed-meshheading:9525342-Humans, pubmed-meshheading:9525342-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:9525342-Insulin-Like Growth Factor I, pubmed-meshheading:9525342-Lumbar Vertebrae, pubmed-meshheading:9525342-Male, pubmed-meshheading:9525342-Peptide Fragments, pubmed-meshheading:9525342-Procollagen, pubmed-meshheading:9525342-Receptors, Somatotropin
pubmed:year
1998
pubmed:articleTitle
Bone mineral, histomorphometry, and body composition in adults with growth hormone receptor deficiency.
pubmed:affiliation
Stanford University School of Medicine, California, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.