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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-5-18
|
| pubmed:databankReference | |
| pubmed:abstractText |
The ETS gene family encodes a group of proteins that function as transcription factors under physiological conditions and, if aberrantly expressed, can lead to cellular transformation. ETS transcription factors are characterized by a unique conserved DNA binding domain. A subset of these proteins is rearranged with EWS in Ewing tumors (ET). We recently described a spectrum of ETS genes coexpressed with EWS-FLI1 in an ETcell line to define proteins that potentially compete in target site selection. We now report on the cloning and characterization of a novel ETS family member, ELFR, displaying 92% homology to ELF-1 in its DNA binding domain while diverging in the rest of the protein. ELFR expression was found in a very tissue restricted pattern with the highest abundancy in placenta. We also report the chromosomal assignment of ELFR and ELF-1 to Xq26 and 13q13, respectively, by means of fluorescence in-situ hybridization (FISH).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0378-1119
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
27
|
| pubmed:volume |
210
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
71-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9524226-Amino Acid Sequence,
pubmed-meshheading:9524226-Chromosome Mapping,
pubmed-meshheading:9524226-Chromosomes, Human, Pair 13,
pubmed-meshheading:9524226-Cloning, Molecular,
pubmed-meshheading:9524226-DNA-Binding Proteins,
pubmed-meshheading:9524226-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:9524226-Genes, Neoplasm,
pubmed-meshheading:9524226-Genes, Reporter,
pubmed-meshheading:9524226-Humans,
pubmed-meshheading:9524226-In Situ Hybridization, Fluorescence,
pubmed-meshheading:9524226-Molecular Sequence Data,
pubmed-meshheading:9524226-RNA, Messenger,
pubmed-meshheading:9524226-Sarcoma, Ewing,
pubmed-meshheading:9524226-Sequence Alignment,
pubmed-meshheading:9524226-Sequence Analysis, DNA,
pubmed-meshheading:9524226-Transcription Factors,
pubmed-meshheading:9524226-Tumor Cells, Cultured,
pubmed-meshheading:9524226-X Chromosome
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.
|
| pubmed:affiliation |
Children's Cancer Research Institute (CCRI), St. Anna Kinderspital, Kinderspitalgasse 6, A-1090, Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|