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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-4-9
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pubmed:abstractText |
The mammalian gamma-aminobutyric acid type A (GABA(A)) receptor, a likely target of anesthetic action, exhibits remarkable subunit heterogeneity. In vitro expression studies suggest that there is subunit specificity to anesthetic responses at the GABA(A) receptor. The authors tested whether genetically engineered mice that lack the beta3 subunit of the GABA(A) receptor differed in their sensitivities to several general anesthetic agents.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
775-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9523823-Anesthetics, General,
pubmed-meshheading:9523823-Animals,
pubmed-meshheading:9523823-Dose-Response Relationship, Drug,
pubmed-meshheading:9523823-Enflurane,
pubmed-meshheading:9523823-Halothane,
pubmed-meshheading:9523823-Hypnotics and Sedatives,
pubmed-meshheading:9523823-Mice,
pubmed-meshheading:9523823-Mice, Knockout,
pubmed-meshheading:9523823-Receptors, GABA-A,
pubmed-meshheading:9523823-Reflex,
pubmed-meshheading:9523823-Structure-Activity Relationship
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pubmed:year |
1998
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pubmed:articleTitle |
Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor.
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pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA. jjq@pccm46.anes.upmc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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