Linked Life Data

9523207

Source:http://linkedlifedata.com/resource/pubmed/id/9523207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-5-27
pubmed:abstractText
As we begin the long march toward genetic dissection of complex traits, it becomes necessary to develop optimum study designs and retool ourselves to face the emerging new challenges. Key issues pertaining to the design of genomic scans are reviewed, including: sampling unit, definition and refinement of phenotype, genotyping issues, one-stage vs. two-stage strategies, sample size and power, and cost and feasibility. It is emphasized that false positives should not be minimized in isolation from the issue of false negatives. Striking a practical balance between the two error rates is suggested. In terms of future directions to pursue, three areas are suggested: meta-analysis for pooling linkage results from multiple scans, rapid multivariate screening methods for increased power to detect quantitative trait loci (QTLs), and classification and regression trees (CART) methodology for handling heterogeneity and interactions. Finally, three recommendations are proposed for genomic scans. First, so as to minimize false negatives for a fixed sample size, it is recommended that we tolerate/accept a reasonable rate of false positives, on average, one false positive per individual scan. Second, so as to enable the use of relatively strict significance levels for interpreting the results from a genomic scan, it is highly recommended that the sample size be derived based on a significance level of at most 0.01 (and not 0.05) and 90% power (and not 80%). Third, it is recommended that the stringent significance levels suggested by Lander and Kruglyak be used when pooling evidence from multiple genomic scans (and not at the level of individual scans).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0741-0395
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-18
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
CAT scans, PET scans, and genomic scans.
pubmed:affiliation
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA. rao@wubios.wustl.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review