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rdf:type |
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lifeskim:mentions |
umls-concept:C0024264,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0108779,
umls-concept:C0221198,
umls-concept:C0936012,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1512941,
umls-concept:C1706438,
umls-concept:C1879547,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
1998-5-14
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pubmed:abstractText |
The onset and persistence of psoriatic lesions are linked to the presence of an inflammatory infiltrate of CD3+ lymphocytes that includes CD4+ and CD8+ subsets. Since a primary susceptibility factor for psoriasis is the Class I HLA-Cw6 molecule, we set out to learn more about the features of the epidermal CD8+ lymphocytes. The markers tested were GMP-17, a cytotoxic granule protein found in activated cytotoxic lymphocytes (CTLs), and the alpha chain of the IL-2 receptor (CD25), a plasma membrane molecule found on activated T cells. Lymphocytes in lesional skin expressed the GMP-17 protein, whereas lymphocytes in non-lesional skin, resolving lesional skin and normal skin had little or no GMP-17. By flow cytometry analysis, lesional epidermal GMP-17+ cells were CD8+CD3+, with a subpopulation expressing the activation marker CD25+. Due to the abundance of activated GMP-17+CD8+CD3+ lymphocytes (the phenotype of activated cytotoxic cells) in psoriatic lesions compared to non-lesional and normal skin, we hypothesize that they are contributing directly to the psoriatic phenotype.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NKG7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(A)-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TIA1 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0303-6987
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-88
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9521496-Antigens, CD3,
pubmed-meshheading:9521496-Antigens, CD8,
pubmed-meshheading:9521496-Epidermis,
pubmed-meshheading:9521496-Flow Cytometry,
pubmed-meshheading:9521496-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:9521496-Humans,
pubmed-meshheading:9521496-Immunohistochemistry,
pubmed-meshheading:9521496-Lymphocyte Activation,
pubmed-meshheading:9521496-Lymphocytes,
pubmed-meshheading:9521496-Membrane Proteins,
pubmed-meshheading:9521496-Phenotype,
pubmed-meshheading:9521496-Poly(A)-Binding Proteins,
pubmed-meshheading:9521496-Proteins,
pubmed-meshheading:9521496-Psoriasis,
pubmed-meshheading:9521496-RNA-Binding Proteins,
pubmed-meshheading:9521496-Skin,
pubmed-meshheading:9521496-T-Lymphocyte Subsets,
pubmed-meshheading:9521496-T-Lymphocytes, Cytotoxic
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pubmed:year |
1998
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pubmed:articleTitle |
Intraepidermal lymphocytes in psoriatic lesions are activated GMP-17(TIA-1)+CD8+CD3+ CTLs as determined by phenotypic analysis.
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pubmed:affiliation |
Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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