|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003250,
umls-concept:C0005767,
umls-concept:C0020855,
umls-concept:C0020860,
umls-concept:C0022646,
umls-concept:C0024204,
umls-concept:C0024264,
umls-concept:C0024399,
umls-concept:C0450127,
umls-concept:C0522536,
umls-concept:C1280500
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1998-4-9
|
|
pubmed:abstractText |
Optimizing therapeutic monoclonal antibody (mAb) depends on the incorporation of the necessary effector functions and the development of hypoantigenic "humanized" antibodies by genetic engineering, which then need to be tested in appropriate preclinical trials.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0041-1337
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
632-41
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:9521196-Animals,
pubmed-meshheading:9521196-Antibodies, Monoclonal,
pubmed-meshheading:9521196-Antigens, CD4,
pubmed-meshheading:9521196-CD4 Lymphocyte Count,
pubmed-meshheading:9521196-Dose-Response Relationship, Immunologic,
pubmed-meshheading:9521196-Graft Rejection,
pubmed-meshheading:9521196-Humans,
pubmed-meshheading:9521196-Immunoglobulin G,
pubmed-meshheading:9521196-Immunoglobulin Isotypes,
pubmed-meshheading:9521196-Immunosuppressive Agents,
pubmed-meshheading:9521196-Kidney Transplantation,
pubmed-meshheading:9521196-Lymph Nodes,
pubmed-meshheading:9521196-Macaca fascicularis,
pubmed-meshheading:9521196-Male,
pubmed-meshheading:9521196-Recombinant Fusion Proteins
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Humanized IgG1 and IgG4 anti-CD4 monoclonal antibodies: effects on lymphocytes in the blood, lymph nodes, and renal allografts in cynomolgus monkeys.
|
|
pubmed:affiliation |
Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston 02114, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
