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rdf:type |
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lifeskim:mentions |
umls-concept:C0007586,
umls-concept:C0019704,
umls-concept:C0026255,
umls-concept:C0086418,
umls-concept:C0178539,
umls-concept:C0208973,
umls-concept:C1257888,
umls-concept:C1334043,
umls-concept:C1419038,
umls-concept:C1512977,
umls-concept:C1517892,
umls-concept:C1521761,
umls-concept:C1704666,
umls-concept:C1834765
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pubmed:issue |
7
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pubmed:dateCreated |
1998-5-1
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pubmed:abstractText |
Several important and possibly interrelated functions have been identified for the HIV-1 accessory gene product Vpr. These include import of the HIV reverse transcription complex into the nucleus of nondividing cells, cellular differentiation including cell cycle arrest at the G2/M phase border, immune suppression, and enhancement of virus replication. We have cloned a candidate Vpr ligand, termed human Vpr interacting protein (hVIP/MOV34), by using a yeast two-hybrid assay. This gene is homologous to a simultaneously identified 34-kDa human mov34 homologue. The MOV34 family includes proteins that function as transcriptional and proteolytic regulators of cell growth and differentiation. We demonstrate direct interactions between the putative ligand hVIP/MOV34 and Vpr in vitro and in vivo. hVIP/MOV34 localizes to the nucleus and appears to function as a component of the cell cycle cascade. We observe an association between the induction of cell cycle arrest at the G2/M phase border by Vpr and a change in the subcellular localization of hVIP/MOV34 from a nuclear to a perinuclear localization. This was further associated with the inhibition of maturation promoting factor-associated histone H1 kinase activity. We conclude that hVIP/MOV34 is involved in the regulation of the cell cycle and a likely cellular cofactor for HIV-1 Vpr.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1550494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1706590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1717476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1741615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1825343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1827422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-1837787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2136707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2138713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2231712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2474678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2524599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2547163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-2569363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-3112559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-3293803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-6345556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-6425302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7474100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7531918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7571402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7648876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7708721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7724608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7815499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7815556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-7933064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8007957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8041786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8178448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8195203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8411397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8440020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8510229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-8551605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9052734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9094673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9261351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9334723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9341143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9520381-9362495
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3419-24
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9520381-Humans,
pubmed-meshheading:9520381-Proteins,
pubmed-meshheading:9520381-Mitosis,
pubmed-meshheading:9520381-Amino Acid Sequence,
pubmed-meshheading:9520381-HeLa Cells,
pubmed-meshheading:9520381-Molecular Sequence Data,
pubmed-meshheading:9520381-Transcription, Genetic,
pubmed-meshheading:9520381-Cell Cycle,
pubmed-meshheading:9520381-G2 Phase,
pubmed-meshheading:9520381-Gene Expression Regulation,
pubmed-meshheading:9520381-Recombinant Proteins,
pubmed-meshheading:9520381-RNA-Binding Proteins,
pubmed-meshheading:9520381-Retroviridae Proteins,
pubmed-meshheading:9520381-Gene Products, vpr
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