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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1998-4-24
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pubmed:abstractText |
We have previously shown that the binding of lipoprotein(a) [Lp(a)] to immobilized fibrinogen involves the domain located in kringles IV-5 to IV-8, but not kringle IV-10. In extending those studies to subjects living in Chicago and in the island of Sardinia, we found that about 6% of them had an Lp(a) with Bmax values of 27.7+/-6.0 fmol, which were about 5-8-fold higher than those of controls (3.4+/-2.8 fmol) and in the range of those observed for free apo(a) derived from the Lp(a) of controls (36.6+/-2.9 fmol). This superbinding phenotype was unaffected by age, sex, type of lipid disorder and hypolipidemic agents, and also had a familial incidence. We are currently exploring the hypothesis that this fibrinogen superbinding phenotype is due to conformational changes of apolipoprotein(a) [apo(a)] resulting from the lipid content and composition of the Lp(a) particle and/or sequence anomalies in the kringle domain IV-5 to IV-8.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9163
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9520128-Age Factors,
pubmed-meshheading:9520128-Aged,
pubmed-meshheading:9520128-Apolipoproteins A,
pubmed-meshheading:9520128-Female,
pubmed-meshheading:9520128-Fibrinogen,
pubmed-meshheading:9520128-Humans,
pubmed-meshheading:9520128-Italy,
pubmed-meshheading:9520128-Kringles,
pubmed-meshheading:9520128-Lipoprotein(a),
pubmed-meshheading:9520128-Lysine,
pubmed-meshheading:9520128-Male,
pubmed-meshheading:9520128-Middle Aged,
pubmed-meshheading:9520128-Mutation,
pubmed-meshheading:9520128-Pedigree,
pubmed-meshheading:9520128-Peptide Fragments,
pubmed-meshheading:9520128-Phenotype,
pubmed-meshheading:9520128-Protein Binding,
pubmed-meshheading:9520128-Protein Conformation,
pubmed-meshheading:9520128-Sex Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Lipoprotein(a): identification of subjects with a superbinding capacity for fibrinogen.
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pubmed:affiliation |
Department of Medicine, University of Chicago, IL 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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