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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-4-2
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pubmed:abstractText |
Myometrial tissue rings from postpartum rats (24 h after delivery) were studied in vitro by electric field stimulation, and the alpha1/beta2-adrenoceptor ratio was determined by a radioligand binding technique. Pregnancy-denervated uterine rings were stimulated by long-duration pulses (100 ms). The contractions were inhibited by beta2-agonists (terbutaline and fenoterol) and alpha-antagonists (phentolamine, urapidil and yohimbine) in a concentration-dependent manner. Their effects were not altered by the adrenergic neuron-blocking agent bretylium. The alpha-antagonists (except phentolamine) elicited the same maximal inhibition as the beta2-agonists. Receptor assays revealed that the alpha1/beta2 ratio was about 2 in the measured uteri. It was concluded that the inhibitory effects of alpha-antagonists and beta2-agonists are mediated via non-synaptic adrenoceptors of the denervated postpartum rat uterus. The same inhibitory activity could be explained by the greater amount of alpha-receptors. It is believed that this is the first functional proof of the existence of non-synaptic alpha1-adrenoceptors in smooth muscle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fenoterol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Terbutaline
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9519814-Adrenergic beta-Agonists,
pubmed-meshheading:9519814-Animals,
pubmed-meshheading:9519814-Binding Sites,
pubmed-meshheading:9519814-Electric Stimulation,
pubmed-meshheading:9519814-Female,
pubmed-meshheading:9519814-Fenoterol,
pubmed-meshheading:9519814-Male,
pubmed-meshheading:9519814-Myometrium,
pubmed-meshheading:9519814-Postpartum Period,
pubmed-meshheading:9519814-Radioligand Assay,
pubmed-meshheading:9519814-Rats,
pubmed-meshheading:9519814-Rats, Sprague-Dawley,
pubmed-meshheading:9519814-Receptors, Adrenergic, alpha,
pubmed-meshheading:9519814-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:9519814-Receptors, Adrenergic, beta,
pubmed-meshheading:9519814-Synapses,
pubmed-meshheading:9519814-Terbutaline,
pubmed-meshheading:9519814-Uterine Contraction,
pubmed-meshheading:9519814-Uterus
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pubmed:year |
1998
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pubmed:articleTitle |
Evidence of non-synaptic regulation of postpartum uterine contractility in the rat.
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pubmed:affiliation |
Department of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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