Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-4-7
|
| pubmed:abstractText |
Several large-scale clinical trials have shown that lipid-lowering interventions are associated with reduced coronary events and mortality. However, whether dyslipidemias have a detrimental effect on the evolution of myocardial infarction (MI) is still unknown. To examine whether dyslipidemias can aggravate myocardial vulnerability following MI, 165 patients with a first MI were studied. All patients underwent measurements of serum lipid profiles 1 week and 3 months after MI, a radionuclide ventriculographic study, and a coronary angiographic study. The patients were divided into 3 groups according to their 3-month serum cholesterol levels (group 1, <200 mg/dl; group 2, 200 to 240 mg/dl; group 3, >240 mg/dl). Groups 1, 2, and 3 consisted of 66, 59, and 40 patients, respectively. Group 3 had a higher Gensini score than groups 1 and 2, although this was not statistically significant (p = 0.13). The postinfarct left ventricular ejection fraction (LVEF) was highest in group 1 (53 +/- 13%), at mid level in group 2 (43 +/- 14%), and lowest in group 3 (35 +/- 11%) (p < 0.0001). A significant negative correlation between 3-month low-density lipoprotein (LDL) cholesterol (r = -0.55, p < 0.0001) and the postinfarct LVEF was found. The product of peak creatine kinase (CK(MAX)) and time to CK(MAX) (p = 0.001), and patency of the infarct-related artery (p = 0.009), rather than variables of coronary atherosclerosis, were also independent predictors of the postinfarct LVEF. Increases in 1-week LDL cholesterol and decreases in 1-week high-density lipoprotein cholesterol were associated with a higher CK(MAX) and a lower patency rate of the infarct-related artery, respectively. This study revealed that dyslipidemias per se, especially LDL cholesterol, had a detrimental effect on the postinfarct LVEF; this effect might be independent of the atherogenic properties of dyslipidemias.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0002-9149
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
81
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
531-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9514445-Aged,
pubmed-meshheading:9514445-Cholesterol, LDL,
pubmed-meshheading:9514445-Coronary Angiography,
pubmed-meshheading:9514445-Creatine Kinase,
pubmed-meshheading:9514445-Female,
pubmed-meshheading:9514445-Gated Blood-Pool Imaging,
pubmed-meshheading:9514445-Humans,
pubmed-meshheading:9514445-Hyperlipidemias,
pubmed-meshheading:9514445-Linear Models,
pubmed-meshheading:9514445-Male,
pubmed-meshheading:9514445-Middle Aged,
pubmed-meshheading:9514445-Myocardial Infarction,
pubmed-meshheading:9514445-Stroke Volume,
pubmed-meshheading:9514445-Systole,
pubmed-meshheading:9514445-Vascular Patency,
pubmed-meshheading:9514445-Ventricular Function, Left
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Dyslipidemias have a detrimental effect on left ventricular systolic function in patients with a first acute myocardial infarction.
|
| pubmed:affiliation |
Department of Internal Medicine (Cardiology), National Taiwan University Hospital, Taipei, Republic of China.
|
| pubmed:publicationType |
Journal Article
|