|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008243,
umls-concept:C0014822,
umls-concept:C0016832,
umls-concept:C0204727,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0205460,
umls-concept:C0441655,
umls-concept:C0678594,
umls-concept:C0679622,
umls-concept:C0680730,
umls-concept:C1148554
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1998-5-6
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|
pubmed:abstractText |
In the course of screening for small-molecule modulators of erythropoietin gene expression, five destruxins were isolated from the fungal culture of OS-F68576. The structures were elucidated by extensive 1H and 13C NMR spectroscopy and by hydrolytic modification. One compound (destruxin-A4 chlorohydrin, 1) is a novel destruxin. All these compounds induced erythropoietin gene expression 5-fold at concentration of 0.2-2 microM.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0163-3864
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
61
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
290-3
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|
pubmed:dateRevised |
2011-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:9514014-Cell Line,
pubmed-meshheading:9514014-Depsipeptides,
pubmed-meshheading:9514014-Erythroid Precursor Cells,
pubmed-meshheading:9514014-Erythropoietin,
pubmed-meshheading:9514014-Fermentation,
pubmed-meshheading:9514014-Fungi,
pubmed-meshheading:9514014-Gene Expression,
pubmed-meshheading:9514014-Humans,
pubmed-meshheading:9514014-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9514014-Peptides, Cyclic,
pubmed-meshheading:9514014-Recombinant Proteins,
pubmed-meshheading:9514014-Stimulation, Chemical
|
|
pubmed:year |
1998
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|
pubmed:articleTitle |
Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: isolation, structure determination, and biological activity as an inducer of erythropoietin.
|
|
pubmed:affiliation |
MYCOsearch, OSI Pharmaceuticals, Durham, North Carolina 27707, USA.
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pubmed:publicationType |
Journal Article
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