Linked Life Data

9512900

Source:http://linkedlifedata.com/resource/pubmed/id/9512900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-5-14
pubmed:abstractText
Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 benign and 10 malignant tumours). In 23 urine samples from patients with malignant bone tumour tested before any treatment, LIF was detectable in eight cases (34.7%). High LIF levels were found in all supernatants from malignant tumour cultures and in supernatant from 12 of the 14 benign tumours cultured. LIF was never detected in control urine samples or supernatants from normal cancelous bone cultures. These first in vivo data concerning LIF in primary bone tumours raise the question as to the cellular origin of this multifunctional cytokine and its potential role in solid bone tumours and bone tumour resorption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1043-4666
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Increased levels of leukaemia inhibitory factor (LIF) in urine and tissue culture supernatant from human primary bone tumours.
pubmed:affiliation
Clinique Chirurgicale Orthopédique, Hôtel-Dieu, Nantes, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't