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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-5-13
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pubmed:abstractText |
In this study we report on a novel natural target of the paired domain transcription factor PAX 8 in the enhancer element of the human thyroperoxidase gene, one of the most important thyroid differentiation markers. It is the primary enzyme involved in thyroid hormone synthesis and PAX 8 has been previously identified as an activating factor of the rat thyroperoxidase gene promoter. In vitro, PAX 8 binds a cis element of the human enhancer and its exogenous expression induces the enhancer activity in co-transfection experiments in Cos-7 cells. When mutated at this binding site, the enhancer is no longer activated by PAX 8. Our finding strengthens the PAX 8 role in the maintenance of thyroid differentiation and in particular in the tissue-specific thyroperoxidase gene expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1320763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1406708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1508216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1723950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1732732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1735431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-1922026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2158317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2174102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2560810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2583123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2610358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-2744487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-3349904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-7739566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8049251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8145764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8241771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8406007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8617244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-8652674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9512459-9002992
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
331 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9512459-Animals,
pubmed-meshheading:9512459-COS Cells,
pubmed-meshheading:9512459-DNA-Binding Proteins,
pubmed-meshheading:9512459-Enhancer Elements, Genetic,
pubmed-meshheading:9512459-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9512459-Humans,
pubmed-meshheading:9512459-Nuclear Proteins,
pubmed-meshheading:9512459-Paired Box Transcription Factors,
pubmed-meshheading:9512459-Peroxidases,
pubmed-meshheading:9512459-Rats,
pubmed-meshheading:9512459-Thyroid Gland,
pubmed-meshheading:9512459-Trans-Activators,
pubmed-meshheading:9512459-Transfection
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pubmed:year |
1998
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pubmed:articleTitle |
PAX 8 activates the enhancer of the human thyroperoxidase gene.
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pubmed:affiliation |
Istituto di Medicina Sperimentale, CNR, Viale C. Marx 15, 00137 Roma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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