| pubmed-article:9512405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9512405 | lifeskim:mentions | umls-concept:C0001563 | lld:lifeskim |
| pubmed-article:9512405 | lifeskim:mentions | umls-concept:C0027756 | lld:lifeskim |
| pubmed-article:9512405 | lifeskim:mentions | umls-concept:C0286862 | lld:lifeskim |
| pubmed-article:9512405 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:9512405 | lifeskim:mentions | umls-concept:C0678536 | lld:lifeskim |
| pubmed-article:9512405 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9512405 | pubmed:dateCreated | 1998-4-29 | lld:pubmed |
| pubmed-article:9512405 | pubmed:abstractText | We recently showed that s.c. injections of a nonimmunosuppressant FK506 binding protein-12 (FKBP-12) ligand (V-10,367) accelerates nerve regeneration in the rat sciatic nerve crush model. Here we examined the oral efficacy of this compound for speeding nerve regeneration. Rats receiving V-10,367 (5, 15 or 50 mg/kg/day) by oral gavage all demonstrated an increase in nerve regeneration compared to vehicle-treated controls. Functional recovery was observed earliest and axonal calibers of regenerating axons in the soleus nerve were largest in the 15 mg/kg group, mean axonal areas being increased by 66% compared to controls. Orally active nonimmunosuppressant FKBP-12 ligands may be useful for the treatment of human peripheral nerve disorders. | lld:pubmed |
| pubmed-article:9512405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9512405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9512405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9512405 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9512405 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:9512405 | pubmed:author | pubmed-author:ChaturvediPP | lld:pubmed |
| pubmed-article:9512405 | pubmed:author | pubmed-author:WangM SMS | lld:pubmed |
| pubmed-article:9512405 | pubmed:author | pubmed-author:GoldB GBG | lld:pubmed |
| pubmed-article:9512405 | pubmed:author | pubmed-author:Zeleny-Pooley... | lld:pubmed |
| pubmed-article:9512405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9512405 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9512405 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9512405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9512405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9512405 | pubmed:pagination | 553-8 | lld:pubmed |
| pubmed-article:9512405 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
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| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:meshHeading | pubmed-meshheading:9512405-... | lld:pubmed |
| pubmed-article:9512405 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9512405 | pubmed:articleTitle | Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration. | lld:pubmed |
| pubmed-article:9512405 | pubmed:affiliation | Center for Research on Occupational and Environmental Toxicology/L606 and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland 97201-3098, USA. | lld:pubmed |
| pubmed-article:9512405 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9512405 | lld:pubmed |
