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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1998-4-29
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pubmed:abstractText |
We recently showed that s.c. injections of a nonimmunosuppressant FK506 binding protein-12 (FKBP-12) ligand (V-10,367) accelerates nerve regeneration in the rat sciatic nerve crush model. Here we examined the oral efficacy of this compound for speeding nerve regeneration. Rats receiving V-10,367 (5, 15 or 50 mg/kg/day) by oral gavage all demonstrated an increase in nerve regeneration compared to vehicle-treated controls. Functional recovery was observed earliest and axonal calibers of regenerating axons in the soleus nerve were largest in the 15 mg/kg group, mean axonal areas being increased by 66% compared to controls. Orally active nonimmunosuppressant FKBP-12 ligands may be useful for the treatment of human peripheral nerve disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
553-8
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9512405-Administration, Oral,
pubmed-meshheading:9512405-Analysis of Variance,
pubmed-meshheading:9512405-Animals,
pubmed-meshheading:9512405-Carrier Proteins,
pubmed-meshheading:9512405-DNA-Binding Proteins,
pubmed-meshheading:9512405-Heat-Shock Proteins,
pubmed-meshheading:9512405-Immunosuppressive Agents,
pubmed-meshheading:9512405-Injections, Subcutaneous,
pubmed-meshheading:9512405-Ligands,
pubmed-meshheading:9512405-Male,
pubmed-meshheading:9512405-Microscopy, Electron,
pubmed-meshheading:9512405-Nerve Crush,
pubmed-meshheading:9512405-Nerve Regeneration,
pubmed-meshheading:9512405-Rats,
pubmed-meshheading:9512405-Rats, Sprague-Dawley,
pubmed-meshheading:9512405-Sciatic Nerve,
pubmed-meshheading:9512405-Tacrolimus Binding Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration.
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pubmed:affiliation |
Center for Research on Occupational and Environmental Toxicology/L606 and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland 97201-3098, USA.
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pubmed:publicationType |
Journal Article
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